Friday, October 28, 2011

What is Spiriva?


What is Spiriva?

Spiriva is an anticholinergic agent. It works by enlarging the airways to allow easier Female Viagra breathing. It comes as a capsule containing dry powder, which is inhaled through the mouth using the HandiHaler device.

Spiriva is used to prevent bronchospasm (narrowing of the airways in the lungs) in people with bronchitis, emphysema, or COPD (chronic obstructive pulmonary disease).
Important information about Spiriva
Spiriva may also be used for other purposes not listed here.
Spiriva capsules are for use only in the HandiHaler device. Use only one capsule at a time. Do not take the capsules by mouth.
Before using Spiriva, tell your doctor if you have narrow-angle glaucoma, or an enlarged prostate or bladder obstruction. If you have any of these conditions, you may not be able to use Spiriva or you may need a dosage adjustment or special tests during treatment.
Spiriva is used to prevent bronchospasm attacks. Do not use Spiriva to treat a bronchospasm attack that has already begun. It will not work fast enough to reverse your symptoms. Use only a fast-acting inhalation medication to treat an attack. Talk with your doctor if any of your medications do not seem to work as well in treating or preventing bronchospasm attacks.
Use Spiriva exactly as it was prescribed for you. Do not use it in larger doses or for longer than recommended by your doctor.
Call your doctor right away if you feel that this medicine is not working as well as usual, or if it makes your condition worse. If it seems like you need to use more of any of your medications in a 24-hour period, talk with your doctor.

Before using Spiriva

Do not use Spiriva if you are allergic to tiotropium, ipratropium (Atrovent) or atropine (Atreza, Sal-Tropine). Spiriva is used to prevent bronchospasm attacks. Do not use Spiriva to treat a bronchospasm attack that has already begun. It will not work fast enough to reverse your symptoms. Use only a fast-acting inhalation medication to treat an attack. Talk with your doctor if any of your medications do not seem to work as well in treating or preventing bronchospasm attacks.
Before using Spiriva, tell your doctor if you are allergic to any drugs, or if you have:
  • narrow-angle glaucoma; or
  • an enlarged prostate or a bladder obstruction.
If you have any of these conditions, you may need a dose adjustment or special tests to safely use Spiriva.
FDA pregnancy category C. It is not known whether Spiriva is harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known if tiotropium passes into breast milk or if it could harm a nursing baby. Do not use Spiriva without telling your doctor if you are breast-feeding a baby.

Spiriva Drug Description


SPIRIVA HandiHaler consists of a capsule dosage form containing a dry powder formulation of tiotropium intended for oral inhalation only with the HandiHaler device.
Each light green, hard gelatin SPIRIVA capsule contains 18 mcg Cialis tiotropium (equivalent to 22.5 mcg tiotropium bromide monohydrate) blended with lactose monohydrate (which may contain milk proteins) as the carrier.
The dry powder formulation within the SPIRIVA capsule is intended for oral inhalation only.
The active component of SPIRIVA HandiHaler is tiotropium. The drug substance, tiotropium bromide monohydrate, is an anticholinergic with specificity for muscarinic receptors. It is chemically described as (1α, 2β, 4 β, 5α, 7β)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide monohydrate. It is a synthetic, non-chiral, quaternary ammonium compound. Tiotropium bromide is a white or yellowish white powder . It is sparingly soluble in water and soluble in methanol.
The structural formula is:
SPIRIVA® HandiHaler® (tiotropium bromide) Structural Formula Illustration
Tiotropium bromide (monohydrate) has a molecular mass of 490.4 and a molecular formula of C19H22NO4S2Br •H2O.
The HandiHaler device is an inhalation device used to inhale the dry powder contained in the SPIRIVA capsule. The dry powder is delivered from the HandiHaler device at flow rates as low as 20 L/min. Under standardized in vitrotesting, the HandiHaler device delivers a mean of 10.4 mcg tiotropium when tested at a flow rate of 39 L/min for 3.1 seconds (2 L total). In a study of 26 adult patients with COPD and severely compromised lung function [mean FEV1 1.02 L (range 0.45 to 2.24 L); 37.6% of predicted (range 16% to 65%)], the median peak inspiratory flow (PIF) through the HandiHaler device was 30.0 L/min (range 20.4 to 45.6 L/min). The amount of drug delivered to the lungs will vary depending on patient factors such as inspiratory flow and peak inspiratory flow through the HandiHaler device, which may vary from patient to patient, and may vary with the exposure time of the SPIRIVA capsule outside the blister pack.

What is tiotropium inhalation (Spiriva)?

Tiotropium inhalation is used to prevent bronchospasm (narrowing of the airways in the lungs) in people with bronchitis, emphysema, or COPD (chronic obstructive pulmonary disease).
Tiotropium inhalation may also be used for other purposes not listed in this medication guide.

What are the possible side effects of tiotropium inhalation (Spiriva)?

Stop using tiotropium inhalation and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
  • tongue swelling or redness;
  • sores or white patches of your mouth, lips, or tongue; or
  • urinating less than usual or not at all.
Less serious side effects may include:
  • dry mouth, cough, hoarseness;
  • blurred vision;
  • trouble swallowing;
  • nausea, constipation, upset stomach;
  • stuffy nose, nosebleed;
  • fast heart rate;
  • drowsiness; or
  • white patches in your mouth or throat.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about tiotropium inhalation (Spiriva)?

Tiotropium capsules are for use only in the HandiHaler device. Use only one capsule at a time. Do not take the capsules by mouth.
Before using this medication, tell your doctor if you have narrow-angle glaucoma, or an enlarged prostate or bladder obstruction. If you have any of these conditions, you may not be able to use tiotropium inhalation or you may need a dosage adjustment or special tests during treatment.
Tiotropium inhalation is used to prevent bronchospasm attacks. Do not use this medication to treat a bronchospasm attack that has already begun. It will not work fast enough to reverse your symptoms. Use only a fast-acting inhalation medication to treat an attack. Talk with your doctor if any of your medications do not seem to work as well in treating or preventing bronchospasm attacks.
Use this medication exactly as it was prescribed for you. Do not use it in larger doses or for longer than recommended by your doctor.
Call your doctor right away if you feel that this medicine is not working as well as usual, or if it makes your condition worse. If it seems like you need to use more of any of your medications in a 24-hour period, talk with your doctor.